The former leader of the free world and Clooney looked to be headed to some formal event as they were wearing suits without ties.
They were likely on their way to a charity dinner for The Clooney Foundation for Justice, Hollywood Life reported.
The foundation, founded by the Clooneys, is devoted to marginalized communities who have fallen victim to human rights abuses.
Barack Obama (left) and George Clooney (right) were photographed on Sunday evening sailing on Lake Como in northern Italy
They were joined by their better halves – Amal Clooney (right) and Michelle Obama (left)
During the boat ride, the former president made himself useful by taking photographs as unidentified guests on the boat look on
The former president and his friend made sure to help the former first lady off the boat
George Clooney was seen walking along a red and blue bridge from the dock to the land. He wore a light gray suit.
Obama was a few feet ahead of him. He wore a dark gray suit and a light blue shirt.
Their wives were also in the boat with them, though they were not seen until it docked on the pier.
George Clooney was a gracious host, helping his wife, Amal; the former first lady, Michelle; and the Obamas’ daughter, Malia, off the boat.
The 57-year-old former president; his wife, Michelle, 55; and their two daughters, Sasha, 18, and Malia, 20, are in Lake Como visiting the former ER heartthrob, 58, and his glamorous wife, Amal Clooney, 41, at their Villa Oleandra in Laglio.
During Obama’s eight years in office, Clooney was one of his most ardent supporters.
The Obamas are spending the weekend at Clooney’s Villa Oleandra in Laglio, Italy
The Obamas and Clooney have been friends since Barack Obama’s time in the White House, during which the former ER actor was one of his biggest supporters
George Clooney extends his hand in order to help his wife, Amal, onto the dock. Michelle Obama is seen sitting in the boat looking on
Barack Obama and George Clooney emerged from the boat and crossed a red and blue bridge to get to land
Both Obama and Clooney were dressed for business, wearing suits without ties
The pair were headed to a charity dinner to benefit a foundation founded by George and Amal Clooney
Amal Clooney appeared to be in good spirits as she headed inside for the dinner to benefit the charity she co-founded with her husband
George Clooney helps Malia Obama onto the wooden walkway after the boat docks. Barack Obama is seen far right while Michelle Obama and Amal Clooney are seen far left
The former first family is in town until Monday.
Their European vacation began last week when they landed in France and spent time on the French Riviera with good friends Bono and The Edge.
The foursome traveled to Avignon by private jet, just days after Sasha graduated from high school in front of her proud parents and her older sibling.
From France, the Obamas flew via private jet to Italy, where they stopped in Milan.
The governor of Laglio has decreed that fines of 500 euros ($565) will be in place for any vessel or vehicle approaching within 300ft of the Villa Oleandra, which is usually accessible to the public unlike typical A-list properties.
The Obamas took their private jet to Milan from Provence where they are believed to have been staying at a $60,000-a-week villa in the Châteauneuf-du-Pape wine region.