Health chiefs today recalled dozens of batches of blood pressure pills because they were found to contain one of the world’s most explosive chemicals.
Pharmacies stocking the affected medicines containing irbesartan and losartan were pulled because of the cancer-causing impurity.
Some of the pills – which are taken by millions of Britons – have been on the market for two years.
The Medicines and Healthcare products Regulatory Agency, which polices the safety of drugs used in Britain, said the affected batches contained azido-tetrazole.
Government officials warned the substance – considered by some to be the world’s most explosive chemical – may increase the risk of cancer.
It is the latest in a line of drug recalls of sartan-type medications, which may have been exposed to cancer-causing chemicals in factories in China and India.
The MHRA insisted the measure was merely a precaution and there was no proof it has caused any harm to patients.
Pharmacies stocking the affected medicines containing irbesartan and losartan (shown above) have been pulled because they were found to contain one of the world’s most explosive chemicals
There is also no evidence any of the pills have exploded.
It also said the move only applied to pharmacies and wholesalers stocking the 31 batches supplied by Bristol Laboratories Limited, Brown & Burk UK Limited and Teva UK Limited.
TIMELINE OF COMMON BLOOD-PRESSURE DRUGS’ RECENT RECALLS
2012 – The blood-pressure medication valsartan is thought to have been contaminated with the cancer-causing, rocket-fuel chemical NDMA as far back as 2012.
European regulators warned last year the medication’s main manufacturer in China – Zhejiang Huahai Pharmaceutical – changed its manufacturing process seven years ago, which may have been to blame.
July 5, 2018 – The UK recalled the drug over growing concerns.
Many EU authorities then followed suit.
The European Medicines Agency said it was working to establish how long, and at what levels, patients might have been exposed to NDMA.
July 17 – The US Food and Drug Administration ordered a ban on valsartan’s prescription.
July 30 – China’s National Health and Family Planning Commission said the drug must not be used for diagnosis or treatment.
January 3, 2019 – The Medicines and Healthcare products Regulatory Agency recalled thousands of medications containing the blood-pressure drug irbesartan over NDEA fears.
The government-run body issued an alert over four batches of the medication and pulled the products – made by Actavis, now known as Accord – as a ‘precautionary measure’.
Britons taking the affected pills were told not to immediately stop taking them because suddenly stopping a course of medicine can be risky.
Other blood pressure pills containing losartan and irbesartan are still available.
Dr June Raine, chief executive of the MHRA, said: ‘Patient safety is our watchword.
‘We’re recalling batches of certain sartan-containing as precautionary measure while we continue our investigation.
‘It’s important that healthcare professionals check their stock to quarantine and return these batches.
‘If you’ve been taking one of the affected products, speak with your doctor or pharmacist before stopping any treatment – they can address any concerns and can advise you on the best course of action.’
Cambridge scientist Dr Ljiljana Fruk described azido-tetrazole as the the world’s ‘most explosive chemical’ in 2019.
Speaking on the BBC’s The Naked Scientists radio show, the chemical expert said: ‘So the most explosive chemical was made in 2011 in the lab.
‘[It] Never went out of the lab, it was made in a special chamber and it’s called azidotetrazole.
‘So that’s a molecule that has 14 nitrogens in its own structure, and because of these constrained nitrogen bonds it’s very explosive.
She added: ‘Some scientists said that this molecule could explode even if you look at it, because you know it really reacts on a tiniest amount of pressure.
‘It’s even more explosive than TNT and some other explosives. So you know pretty interesting stuff.’
Officials have yet to explain how the impurity may have occurred. They are often caused by contamination in factories or brought on during the manufacturing or storage process.
Exposure to light, temperatures or even reactions with the container that holds the drug can trigger chemical changes.
Overall, more than two-thirds of all active drug ingredients originate in China and India, industry experts estimate, with China accounting for the lion’s share.
It is unclear how many of the affected products will be recalled on the back of today’s announcement.
NHS figures reveal more than 2million prescriptions for drugs containing irbesartan were dished out in England in 2017. Around 165,000 of these are thought to be for Irbesartan Hydrochlorothiazide.