PORTUGAL must overcome their World Cup disappointment, while Italy aim to restore faith in their squad as Euro 2020 qualification draws near.
The star-studded sides have the quality to climb back to the big time, but the Nations League will prove if they have the collective spirit to improve.
Portugal must perform better if they are to keep their European Championships crown[/caption]
What time is kick-off?
The game will be played on Monday, September 10.
Kick-off is scheduled for 7.45pm.
The reverse tie will be held on Saturday, November 17 at the San Siro in Milan.
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How do I watch Portugal vs Italy for free and can I live stream it?
The match is available on Sky Sports Football and Sky Sports Mix, with coverage starting at 7.40pm.
All Sky TV customers can access Sky Sports Mix for free, without needing a Sky Sports package.
Sky Sports subscribers can stream coverage of the game through the official Sky Sports app or via Sky Go.
Alternatively, you can follow all the action on our dedicated SunSport LIVE BLOG.
What is the team news?
Goalkeepers: Rui Patricio (Wolverhampton), Beto (Goztepe), Claudio Ramos (Tondela)
Defenders: Cedric Soares (Southampton), Joao Cancelo (Juventus), Luis Neto (Zenit St Petersburg), Mario Rui (Napoli), Pedro Mendes (Montpellier), Pepe (Besiktas), Raphael Guerreiro (Borussia Dortmund), Ruben Dias (Benfica)
Midfielders: Bruno Fernandes (Sporting Lisbon), Gedson Fernandes (Benfica), Pizzi (Benfica), Renato Sanches (Bayern Munich), Ruben Neves (Wolverhampton), Sergio Oliveira (FC Porto), William Carvalho (Real Betis)
Forwards: Andre Silva (Sevilla), Bernardo Silva (Manchester City), Bruma (RB Leipzig), Gelson Martins (Atletico Madrid), Goncalo Guedes (Valencia), Rony Lopes (Monaco)
Goalkeepers: Gigi Buffon (Parma), Francesco Toldo (Fiorentina)
Defenders: Valerio Bertotto (Udinese), Fabio Cannavaro (Parma), Francesco Coco (Milan), Paolo Maldini (Milan), Alessandro Nesta (Lazio), Giuseppe Pancaro (Lazio), Alessandro Pierini (Fiorentina)
Midfielders: Demetrio Albertini (Milan), Gennaro Gattuso (Milan), Gigi Di Biagio (Inter), Angelo Di Livio (Fiorentina), Stefano Fiore (Udinese), Gianluca Pessotto (Juventus), Alessio Tacchinardi (Juventus), Gianluca Zambrotta (Juventus), Damiano Tommasi (Roma),
Forwards: Alessandro Del Piero (Juventus), Filippo Inzaghi (Lazio), Marco Delvecchio (Roma), Francesco Totti (Roma), Vincenzo Montella (Roma)